Efficiency of Immunization with the Hatching Fluid of Toxocara canis and Toxascaris leonina eggs against infection with Toxascaris leonina and Toxocara cati larvae

Abstract

The study was aimed to compare between three different routes of administration for immunization of white mice (Balb/c) with hatching fluid of Toxocara canis and Toxascaris leonina eggs against the experimental infection with T.cati and T.leonina. Results showed a significant difference between mean values of larvae recovered from immunized mice compared to control. The immunization efficiencies that resulted from the different injection routes ranged from 56.25% in mice immunized subcutaneously with hatching fluid of T.canis eggs against experimental infection with T.cati eggs to 68.18% in mice immunized intraperitonially. Mice immunized with T.canis against T.leonina had an efficiency ranged from 61.22% when they immunized intraperitonially to 67.34 % when they immunized subcutaneously. The immunization efficiency in mice injected with T.leonina against T.cati was ranged from 42.61% when they immunized subcutaneously to 46.87% when they immunized intraperitonially. Mice immunized with T.leonina against the experimental infection with the same worm had an immunization efficiency ranged from 62.75% when immunized intraperitonially to 65.05% when immunized subcutaneously. It was concluded that the intraperitonial route is more efficient to stimulate immunity against T.cati, while subcutaneous route against T.leonina. In addition immunization by hatching fluid of T.canis is better than T.leonina against experimental infection with T.cati.