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Title: Adiponectin and leptin as discriminating biomarkers between pre-metabolic and metabolic syndromes in patients with type 2 diabetes
Authors: M.S.M. Al-Nimer1, M.M. Mahmood2, R.J. Abd-Alkaliq3
Keywords: Adipocytokines, metabolic syndrome, type 2 diabetes
Issue Date: 2014
Publisher: Journal of Diabetology, June 2014; 2:3
Abstract: An imbalance in adipocytokines is reported in several diseases. The aim of the study was to assess the status of serum adipocytokines (notably leptin and adiponectin) in patients with type 2 diabetes presented with pre-metabolic or metabolic syndrome. This cross-sectional study was conducted in the Department of Pharmacology, College of Medicine in cooperation with department of Biology, College of Science at Al-Mustansiriya University in Baghdad, Iraq. A total of 78 patients with type 2 diabetes with pre-metabolic syndrome (n = 12) and metabolic syndrome (n = 66) of both genders were enrolled in the study. Data related to the components of metabolic syndrome including anthropometric measurements, blood pressure and fasting serum lipid profile were collected. Serum adiponectin and leptin were determined using the enzyme linked immunosorbent assay (ELISA). In patients with type 2 diabetes the levels of several components of metabolic syndrome were significantly higher than those with pre-metabolic syndrome. Although numerically higher levels of serum adiponectin and leptin levels were observed in subjects with metabolic syndrome (2.479 ± 0.321 pg/ml and 171.44 ± 29.57 pg/ml respectively) compared to pre-metabolic syndrome (2.096 ± 0.327 pg/ml and 148.23 ± 48.88 pg/ml respectively), the difference was not statistically significant. Multivariate analysis revealed non-significant correlation between serum levels of adipocytokines and all components of metabolic syndrome. Non-significant inverse correlations were observed between serum leptin and adiponectin in pre-metabolic (r = - 0.225) and metabolic (r = - 0.148) syndromes. Low serum adiponectin and leptin levels are associated with pre-metabolic syndrome compared to metabolic syndrome and these biomarkers are not good to discriminate between pre-metabolic and metabolic syndrome in patients with type 2 diabetes.
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