Please use this identifier to cite or link to this item: http://37.48.73.109:8080/jspui/jspui/handle/123456789/1376
Title: SYNTHESIS, AND BIOLOGICAL EVALUATION OF NEWLY SUNTHESIZED TRIAZOLOTRIAZINES AND TRIAZOLOTRAIZINES DERIVATIVES
Authors: Hameed M. Mohammed
Keywords: Triazolo[4,3-b][1,2,4] Pyrimidine, , Amino-1,2,4-triazole, Chloromethyl diphenylphosphanoxide, Indomethacin, Nalidixic acid and Nystatin
Issue Date: 2017
Publisher: J. of University of Anbar for pure science : Vol.11:NO.2: 2017
Abstract: Novel 8-(4-fluorophenyl)-6,6-diphenyl-3-(pyrimidin-4-yl) -5,6,7,8-tetrahydro-6l5-[1,2,4]triazolo [4,3-a][1,3,5]diazaphosphinin-6-ol(5),8-(4-fluorophenyl)-6-phenyl-3-(pyrimidin-4-yl)-7,8-dihydro [1,2,4]triazolo [4,3-b][1,2,4]triazine (6), 8-(4-fluorophenyl)-6-methyl-3-(pyrimidin-4-yl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7(8H)-one (7) and 8-(4-fluorophenyl)-3-(pyrimidin-4-yl)-[1,2,4]triazolo[4,3-b][1,2,4]triazine-6,7(5H,8H)-dione (8) and 7-(pyrimidin-4-yl)-3,4-dihydro-[1,2,4]triazolo[4,e][1,2,4,5,3]tetrazaphosphinine (10), 3-(pyrimidin-4-yl)-1,7-dihydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine (11), 6-(2-chloro-6-fluorophenyl)-3-(pyrimidin-4-yl)-1,5,6,7,8,8a-hexahydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine (12), 3-(pyrimidin-4-yl)-1,7,8,8a-tetrahydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine-6(5H)-thione (13) and 3-(pyrimidin-4-yl)-1,7,8,8a-tetrahydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazin-6(5H)-one (14) have been synthesized via heterocyclization of 3-(pyridin-4yl)-4-amino-5-substituted amino-1,2,4-triazole (3) and 3-(pyridin-4yl)-4-amino-5-hydrazino-1,2,4-triazole (9) with α,β-bifunctional reagents such as chloromethyldiphenyl-phosphanoxide, phenacyl bromide, pyruvic acid, diethyl oxalate, triethylphosphite, triethyl orthoformate, fluorinated benzaldehydes, ethyl chloroformate and carbon disulfide in different experimental conditions. The molecular structures of the synthesized target molecules were elucidated by FT-IR, 1H NMR, 13C NMR and mass spectral data, in addition to the fine elements analysis C.H.N.% data. The antimicrobial and anti-inflammatory effects of the obtained derivatives were evaluated and compared with that of the standard Indomethacin, Nalidixic acid and Nystatin.
URI: http://37.48.73.109:8080/jspui/jspui/handle/123456789/1376
ISSN: 1991-8941
Appears in Collections:البحوث العلمية



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